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Indication & Dosage |
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| Intravenous |
| INCREASED INTRACRANIAL PRESSURE |
| Adult:
100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg. |
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| Intravenous |
| INCREASED INTRACRANIAL PRESSURE |
| Child:
100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg. |
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| Intravenous |
| STATUS EPILEPTICUS |
| Child:
100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg. |
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| Intravenous |
| STATUS EPILEPTICUS |
| Adult:
100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg. |
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| Oral |
| INDUCTION OF GENERAL ANAESTHESIA |
| Child:
2-7 mg/kg over 10-15 seconds; repeated after 1 minute if needed.. Elderly: Dose reduction may be needed. |
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| Oral |
| INDUCTION OF GENERAL ANAESTHESIA |
| Adult:
100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg. |
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| Precautions |
Hypovolaemia; history of severe asthma, severe cardiac disease, severe anaemia, hyperkalaemia, toxaemia, myasthenia gravis, myxoedema; severe renal or hepatic disease; muscular dystrophies, adrenocortical insufficiency; increased intracranial pressure; elderly, pregnancy, lactation. Avoid extravasation or intra-arterial administration. IV inj of concentrated thiopental solution e.g. 5% may cause thrombophloebitis. |
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Potentially Life-threatening
Adverse Drug Reactions |
Coughing, hiccupping, sneezing, muscle twitching, laryngospasm, bronchospasm. IV: tissue necrosis (if extravasation occurs). Intra-arterial: Severe arterial spasm with burning pain, blanching of forearm and hands and gangrene of digits. |
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| Adverse Drug Reactions |
Respiratory depression, arrhythmias, circulatory failure and anaphylactoid reactions. |
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| Interactions |
Possible increase in difficulty in producing anaesthesia in patients taking alcohol or CNS depressants. Additive action with other CNS depressants including sedatives, hypnotics, nitrous oxide or alcohol. Increased hypotension and excitatory effects with phenothiazine antipsychotics. Increased hypnotic effect with antipsychotic. Decreased requirement of thiopental sodium with metoclopramide, sulfisoxazole, aspirin, meprobamate, probenecid and other highly protein bound drugs. |
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